![]() The prevalence of DME has been reported from 3.8% to 23.8% in different studies among diabetic patients. ![]() Diabetic macular edema (DME) is a common manifestation of this vasculopathy that can cause central visual loss and markedly affects the patient’s quality-of-life. Diabetic retinopathy is a disabling microvascular complication, causes vision loss in varying degrees in patients. Keywordsĭiabetes mellitus is a worldwide common chronic disorder with a high burden of disease. Chromium supplementation did not affect the visual acuity and central foveal thickness of patients with non-proliferative diabetic retinopathy and macular edema but reduced the number of IVB injections and HbA1C level. HbA1C and the average number of IVB injections were significantly lower in the chromium group, (P=0.032 and P=0.001, respectively). The linear mixed model analysis showed that the mean CFT reduction was not significantly different between both groups in four follow-up visits (P=0.433, P=0.398 and P=0.630, and P=0.151, respectively). The visual acuity was improved significantly from baseline in all follow-up points in both groups (P < 0.05 for all visits compared to baseline), but there was no significant difference between groups. 51 of them were in chromium, and 39 were in the control group. From 120 eligible patients, 90 patients involved in this study and completed the six months’ follow-up period. Best-Corrected Visual Acuity (BCVA), Central Foveal Thickness (CFT), HbA1c, and the frequency of Intravitreal Bevacizumab (IVB) injection were compared. Patients received the supplementation with or without chromium for 4 months and were followed for six months. Objective of the present study was to investigate the effect of chromium polynicotinate supplementation on the visual acuity and macular thickness of the diabetic macular edema in patients with non-proliferative diabetic retinopathy through a prospective, interventional comparative case series study, was performed in 120 patients.
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